| 产品详情 |
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| Antigenic Specificity | CD8a Molecule (CD8A) |
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| Clone | OX-8 |
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| Host Species | Mouse |
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| Reactive Species | rat |
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| Isotype | IgG1 |
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| Format | Protein A purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Functional Studies (Func),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunoprecipitation (IP),Flow Cytometry (FACS),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling. |
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| Immunogen | High Mw glycoproteins from rat thymocytes |
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| Other Names | cd8|LOC100136450|BB154331|Ly-2|Ly-35|Ly-B|Lyt-2|zgc:136643|CD8|Leu2|MAL|p32|RHACD8-4 |
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| Gene, Accession # | Gene ID: 24930 |
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| Catalog # | ABIN1027698 |
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| Price | |
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| Order / More Info | CD8a Molecule (CD8A) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 19424493, 17785814, 19956764, 12900522, 9551905, 9029123, 1358623, 7016746 |
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