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| Antigenic Specificity | CD79a Molecule, Immunoglobulin-Associated alpha (CD79A) (aa 202-216) |
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| Clone | HM57 |
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| Host Species | Mouse |
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| Reactive Species | human, porcine, mouse, rat, cow, horse, guinea pig, opossum, rabbit, chicken |
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| Isotype | IgG1 |
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| Format | phycoerythrin (PE) conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
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| Immunogen | Synthetic peptide corresponding to amino acids 202-216 of human CD79a |
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| Other Names | CD79A|Ig-alpha|Iga|Igalpha|Ly-54|Ly54|mb-1|IGA|MB-1|IG-alpha |
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| Gene, Accession # | Gene ID: 973,100052219,100190992,281674,12518,681236,100724815 |
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| Catalog # | ABIN302041 |
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| Order / More Info | CD79a Molecule, Immunoglobulin-Associated alpha (CD79A) (aa 202-216) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 17673300, 17114463, 15661879, 15240688, 14764688, 11733573, 7632952, 1747162, 1396979, 2033258, 8515069 |
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