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| Antigenic Specificity | CD79a Molecule, Immunoglobulin-Associated alpha (CD79A) (aa 208-222), (C-Term) |
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| Clone | HM47 |
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| Host Species | Mouse |
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| Reactive Species | chicken, cow, dog, guinea pig, horse, human, mouse, nonhuman primate, porcine, rabbit, rat |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunoprecipitation (IP),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
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| Immunogen | Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a |
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| Other Names | CD79A|Ig-alpha|Iga|Igalpha|Ly-54|Ly54|mb-1|IGA|MB-1|IG-alpha |
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| Gene, Accession # | Gene ID: 973,484483,100052219,100190992,281674,12518,681236,100724815 |
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| Catalog # | ABIN2749135 |
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| Order / More Info | CD79a Molecule, Immunoglobulin-Associated alpha (CD79A) (aa 208-222), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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