| 产品详情 |
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| Product Name | MK-0557 |
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| Description | A potent antagonist of NPY receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively); >7,500-fold selective for Y5 over other NPY receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 µM; increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner; reduces body weight gain in wild-type and diet-induced obese mice when administered at a dose of 30 mg/kg; reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 935765-76-7 MK0557 Y-5 Chinese ovary hamster |
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| Gene, Accession, CAS # | CAS: 328232-95-7 |
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| Catalog # | 22134-1 |
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| Order / More Info | MK-0557 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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