| 产品详情 |
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| Product Name | APY0201 |
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| Description | An inhibitor of PIKFYVE (IC50 = 5.2 nM); selectively inhibits IL-12 family inflammatory cytokine production (IC50s = 8, 99, and >10,000 nM for IL-12p70, IL-12p40, and TNF-α in stimulated human PBMCs); selective for PIKFYVE over a panel of 137 G protein-coupled receptors, enzymes, ion channels, and transporters, and other kinases only exhibiting >50% inhibition at LOK and ITPK1 at a concentration of 300 nM; inhibits Il-12p70 production ex vivo in murine plasma and reduces colonic inflammation in a mouse Il-10-/- cell transfer model of inflammatory bowel disease in a dose-dependent manner |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | APY-0201 APY201 201 IL12 TNFα |
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| Gene, Accession, CAS # | CAS: 1232221-74-7 |
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| Catalog # | 9001589-25 |
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| Price | |
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| Order / More Info | APY0201 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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