| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Fe65 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, mouse, rat |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Western Blot: 1-2 µg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Fe65 Polyclonal Antibody. The major transcript of the Fe65 gene is a neuron-specific mRNA that encodes a nuclear protein whose amino-terminal domain strongly activates the transcription of reporter genes. Fe65 has been implicated in a regulatory and cell signaling mechanism because it contains two different motifs involved in protein binding; a WW domain (a variant of Src homology 3 domains) and a phosphotyrosine interaction domain (PID). Interestingly, the PID domain binds to the same motif present in the conserved cytoplasmic domains of the beta PP and beta PP-like proteins. RNA analyses revealed that Fe65 is predominantly expressed in the brain and in the regions most affected by Alzheimer's disease-associated neuropathology. |
|---|
| Immunogen | n/a |
|---|
| Other Names | APBB1 |
|---|
| Gene, Accession # | Entrez: 11785, 29722, 322; Uniprot: O00213, P46933, Q9QXJ1 |
|---|
| Catalog # | PA1-752 |
|---|
| Price | |
|---|
| Order / More Info | Fe65 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | PubMed: 17170108, 17904250 |
|---|
| 产品资料 |
|
|