| 产品详情 |
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| Antigenic Specificity | Slap |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | bovine, canine, equine, guinea pig, human, mouse, rabbit, rat, zebrafish |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 4-8 µg/mL, Western Blot: 0.2-1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Slap Polyclonal Antibody. SLAP also known as Src-like-adapter protein 1 is a 276 amino acid containing adapter protein, functioning as a negative regulator of T-cell receptor (TCR) signaling. SLAP belonging to the SRC family of cytoplasmic tyrosine kinases contains a SH2 domain and a SH3 domain. This cytoplasmic protein colocalizes with endosomes and is known to inhibit T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. It acts as a negative regulator of positive selection and mitosis of T-cells. SLAP may act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Expression of SLAP is weak in heart, adult brain, placenta, liver, skeletal muscle, kid |
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| Immunogen | n/a |
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| Other Names | Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase, LP, SLA, PCH2D, SLA/LP |
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| Gene, Accession # | Entrez: 100067546, 100349983, 100718201, 211006, 393123, 488852, 51091, 518874, 679383; Uniprot: Q6P6M7, Q803A7, Q9HD40 |
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| Catalog # | PA5-41953 |
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| Price | |
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| Order / More Info | Slap Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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