| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human Cellular tumor antigen p53 (TP53) |
|---|
| Description | Purity > 90% as determined by SDS-PAGE. MW: 45.7kDa. Full Length: 1-393aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
|---|
| Gene, Accession, CAS # | TP53, UniProt: P04637 |
|---|
| Catalog # | RPC24997 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human Cellular tumor antigen p53 (TP53) from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|