| 产品详情 |
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| Product Name | BIIB 021 |
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| Description | A synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC50 values of 0.06, 0.31, and 0.14 µM, respectively. MW: 318.76. Purity ≥99% by HPLC |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine; CNF2024 |
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| Gene, Accession, CAS # | CAS: 848695-25-0 |
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| Catalog # | 2291-5 |
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| Price | |
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| Order / More Info | BIIB 021 from BIOVISION, INC. |
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| Product Specific References | n/a |
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