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| Product Name | Recombinant Human Leukemia inhibitory factor protein (LIF) (Active) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 47.7kDa. Partial: 22-200aa. C-terminal 6xHis-FC-tagged. Homo sapiens (Human). Hepatitis A virus cellular receptor 2(HAVCR2)is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell membrane protein 3; FLJ14428; KIM-3; Tim-3; TIM3; TIMD3 |
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| Gene, Accession, CAS # | HAVCR2, UniProt: Q8TDQ0 |
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| Catalog # | RPC26975 |
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| Order / More Info | Recombinant Human Leukemia inhibitory factor protein (LIF) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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