| 产品详情 |
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| Product Name | all-trans-4-hydroxy Retinoic Acid |
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| Description | A metabolite of all-trans retinoic acid; formed through metabolism of all-trans retinoic acid by CYP26A1, B1, and C1; binds to RARs with a lower affinity than other all-trans retinoic acid metabolites (IC50s = 606, 298, and 892 nM for RARα, RARβ, and RARγ, respectively, in a radioligand binding assay); transactivates RARs with a lower efficacy than other metabolites (EC50s = 791, 64, and 94 nM for RARα, RARβ, and RARγ, respectively) but induces transcription of a reporter plasmid equipotently; inhibits cell growth, halts the cell cycle in the G1 phase, and induces differentiation of NB4 acute promyelocytic leukemia cells (EC50 = 79.8 nM) |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-hydroxy RA|4-OH-atRA |
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| Gene, Accession, CAS # | CAS: 66592-72-1 |
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| Catalog # | 21378-1 |
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| Order / More Info | all-trans-4-hydroxy Retinoic Acid from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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