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| Product Name | TRAIL-R1 to -R4 (human) Flow Cytometry Pack |
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| Description | TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-kappaB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. |
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| Size | 1 set |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS) |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | ABIN2745408 |
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| Order / More Info | TRAIL-R1 to -R4 (human) Flow Cytometry Pack from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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