| 产品详情 |
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| Antigenic Specificity | Cyclophilin B |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | canine, human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Cyclophilin B Polyclonal Antibody. Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressan |
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| Immunogen | n/a |
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| Other Names | Cyp B, Peptidyl-prolyl cis-trans isomerase B, EC 5.2.1.8, PPIase, Rotamase, S-cyclophilin, SCYLP, CYP-S1 |
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| Gene, Accession # | Entrez: 19035, 478337, 5479, 64367; Uniprot: P23284, P24368, P24369 |
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| Catalog # | PA1-027A |
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| Order / More Info | Cyclophilin B Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 11691584, 11700317, 12905473, 15075329, 15546003, 15764595, 16686602, 16784960, 17056599, 17376913, 17727639, 19287346, 19729514, 20333451, 20727922, 20816094, 20943662, 21070240, 21085665, 21115476, 21179577, 21186792, 21282188, 21337297, 21423176, 21551267, 21752938, 22829580, 23001183, 24586203, 26872613, 27122588 |
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