| 产品详情 |
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| Product Name | Ko 143 |
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| Description | Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. Inhibits ABCB1 and ABCC1 at higher concentrations. Rapidly metabolized in rat plasma. Purity 99%. MW (observed): 469.57 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester |
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| Gene, Accession, CAS # | CAS: 461054-93-3 |
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| Catalog # | 3241/1 |
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| Price | |
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| Order / More Info | Ko 143 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 21767647, 22200378, 23028879, 23063411, 23095522, 23822179, 24993496, 25691630, 25928015, 26199091, 26853103, 26983466 |
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