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| Product Name | Recombinant Human Perforin-1 (PRF1) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 103.2kDa. Full Length of Mature Protein: 22-555aa. N-terminal MBP-tagged and C-terminal 6xHis-tagged. Homo sapiens (Human). Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Cytolysin; Lymphocyte pore-forming protein; PFP |
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| Gene, Accession, CAS # | PRF1, UniProt: P14222 |
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| Catalog # | RPC20651 |
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| Order / More Info | Recombinant Human Perforin-1 (PRF1) from BIOMATIK |
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| Product Specific References | n/a |
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