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| Antigenic Specificity | BRAP |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1-4 µg/mL, Immunofluorescence: 1-4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BRAP Polyclonal Antibody. Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. |
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| Immunogen | n/a |
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| Other Names | BRAP2; IMP; RNF52; BRCA1-associated protein; RING finger protein 52; galectin-2-binding protein; impedes mitogenic signal propagation; renal carcinoma antigen NY-REN-63 |
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| Gene, Accession # | Entrez: 8315; Uniprot: Q7Z569 |
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| Catalog # | PA5-66210 |
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| Price | |
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| Order / More Info | BRAP Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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