| 产品详情 |
| Edit |   |
|---|
| Product Name | Linaclotide |
|---|
| Description | A peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa); stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C receptor null mice; increases intestinal transit in wild-type mice when administered at a dose of 100 µg/kg; reduces the number of phosphorylated ERK-positive dorsal horn neurons in the thoracolumbar spinal cord, a marker of nociceptive signaling, following noxious colorectal distension and mechanical hypersensitivity in a mouse model of TNBS-induced colitis |
|---|
| Size | 500 µg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Linzess constipation IBS Constella |
|---|
| Gene, Accession, CAS # | CAS: 851199-59-2 |
|---|
| Catalog # | 24085-500 |
|---|
| Price | |
|---|
| Order / More Info | Linaclotide from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|