| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | HP1 alpha |
|---|
| Clone | monoclonal |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | purified |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Immunofluorescence: 1-10 µg/mL, Immunohistochemistry: 1:100, Western Blot: 1 µg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | HP1 alpha Monoclonal Antibody. Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mou |
|---|
| Immunogen | n/a |
|---|
| Other Names | chromobox homolog 5; HP1 alpha homolog; Antigen p25 |
|---|
| Gene, Accession # | Entrez: 23468; Uniprot: P45973 |
|---|
| Catalog # | MA1-218 |
|---|
| Price | |
|---|
| Order / More Info | HP1 alpha Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|