| 产品详情 |
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| Product Name | Brequinar |
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| Description | A DHODH inhibitor (IC50 = ~20 nM); selective for DHODH over a panel of greater than 400 kinases at 100 nM; induces differentiation of ER-HoxA9, U937, and THP-1 cells in vitro (ED50s = ~1 µM); induces differentiation of tumor cells and reduces tumor growth in a THP-1 mouse xenograft model at 15 mg/kg three times daily or 5 mg/kg per day; induces differentiation of bone marrow leukemic cells and increases survival In a retroviral transduction mouse model of HoxA9 + Meis1 AML |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NSC 368390 |
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| Gene, Accession, CAS # | CAS: 96187-53-0 |
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| Catalog # | 24445-10 |
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| Price | |
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| Order / More Info | Brequinar from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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