| 产品详情 |
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| Product Name | API-2 |
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| Description | Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2. Purity 99%. MW (observed): 320.31 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine. Triciribine, NSC 154020, TCN |
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| Gene, Accession, CAS # | CAS: 35943-35-2 |
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| Catalog # | 2151/10 |
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| Order / More Info | API-2 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 17440074, 19547699, 20042609, 20530739, 20694145, 21518928, 22017877, 22117079, 23789095, 24565756, 25105067, 25749171, 26120935, 26224873 |
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