| 产品详情 |
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| Product Name | BI 78D3 |
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| Description | Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes. Purity 99%. MW (observed): 379.37 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one |
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| Gene, Accession, CAS # | CAS: 883065-90-5 |
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| Catalog # | 3314/10 |
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| Price | |
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| Order / More Info | BI 78D3 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 23675999, 24086109, 26491845, 27293988 |
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