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| Product Name | BIRT 377 |
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| Description | Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available. Purity 98%. MW (observed): 442.13 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione |
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| Gene, Accession, CAS # | CAS: 213211-10-0 |
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| Catalog # | 4776/10 |
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| Price | |
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| Order / More Info | BIRT 377 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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