| 产品详情 |
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| Product Name | NMS 873 |
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| Description | Potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM). Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 μM). Activates the unfolded protein response (UPR) and modulates autophagosome maturation. Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively). Reduces p97-sensitization to trypsin digestion. Purity 98%. MW (observed): 520.67 |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine |
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| Gene, Accession, CAS # | CAS: 1418013-75-8 |
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| Catalog # | 6180/5 |
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| Order / More Info | NMS 873 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 23892893 |
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| 产品资料 |
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