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| Product Name | CCG 203971 |
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| Description | Antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF, α-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGFβ-stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo. Also suppresses PC-3 cell migration in scratch wound assays (IC50 = 4.2 μM). Purity 98%. MW (observed): 408.88 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide |
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| Gene, Accession, CAS # | CAS: 1443437-74-8 |
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| Catalog # | 5277/10 |
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| Order / More Info | CCG 203971 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 28542204 |
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| 产品资料 |
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