| 产品详情 |
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| Product Name | PF 06651600 malonate |
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| Description | Potent and selective JAK3 inhibitor (IC50 = 33.1 μM). Exhibits no significant activity against a panel of other kinases including JAK1, JAK2 and TYK2. Inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. Suppresses Th1 and Th17 T-cell differentiation and function in vitro. Reduces paw swelling in a rat model of arthritis and reduces disease severity in a rat EAE model. Purity 98%. MW (observed): 389.41 |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate |
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| Gene, Accession, CAS # | CAS: 2140301-97-7 |
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| Catalog # | 6506/5 |
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| Order / More Info | PF 06651600 malonate from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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