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| Product Name | PHA 767491 hydrochloride |
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| Description | ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.034 - 0.75, 0.24 - 1.2, 0.25 - 1.1 and 0.46 - 1 μM for cdk9, cdk2, cdk1 and cdk5, respectively). Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2; IC50 = 171 nM). Prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Purity 99%. MW (observed): 249.7 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride |
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| Gene, Accession, CAS # | CAS: 942425-68-5 |
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| Catalog # | 3140/50 |
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| Order / More Info | PHA 767491 hydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 21595939, 23424178, 24902048, 27407105, 27957526 |
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