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Product Name | SKI II |
Description | Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM). Purity 98%. MW (observed): 302.78 |
Size | 50 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol |
Gene, Accession, CAS # | CAS: 312636-16-1 |
Catalog # | 2097/50 |
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Order / More Info | SKI II from TOCRIS BIOSCIENCE
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Product Specific References | PubMed: 20234131, 22759398, 24747173, 26337959, 26576339 |
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