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| Product Name | SN-6 |
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| Description | Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM). Purity 99%. MW (observed): 402.16 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester |
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| Gene, Accession, CAS # | CAS: 415697-08-4 |
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| Catalog # | 2184/50 |
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| Order / More Info | SN-6 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 19118110, 19509218, 20668204, 22472648, 23785474, 25626872, 29955038 |
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