| 产品详情 |
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| Product Name | Sorafenib |
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| Description | Potent Raf inhibitor (IC50 values are 6, 22 and 38 nM for Raf-1, wild-type BRAF and V599E BRAF mutant, respectively). Also inhibits mVEGFR-2, mVEGFR-3, mPDGFR-β, Flt-3, cKIT and VEGFR-2 (IC50 values are 15, 20, 57, 58, 68 and 90 nM, respectively). Inhibits MAPK pathway in colon, pancreatic and breast cancer cells expressing mutant KRAS and mutant or wt BRAF in vitro. Exhibits antitumor activity in colon, breast and non small-cell lung cancer xenograft models. Purity 98%. MW (observed): 464.82 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
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| Gene, Accession, CAS # | CAS: 284461-73-0 |
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| Catalog # | 6814/10 |
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| Order / More Info | Sorafenib from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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