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| Product Name | SPRi 3 |
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| Description | Potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models. Purity 98%. MW (observed): 262.3 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide |
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| Gene, Accession, CAS # | CAS: 1292285-54-1 |
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| Catalog # | 6597/10 |
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| Price | |
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| Order / More Info | SPRi 3 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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