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| Product Name | R 268712 |
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| Description | Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 = 2.5 nM). Exhibits ~5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Orally bioavailable. Purity 98%. MW (observed): 363.39 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[2-Fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol |
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| Gene, Accession, CAS # | CAS: 879487-87-3 |
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| Catalog # | 5288/50 |
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| Order / More Info | R 268712 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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