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| Product Name | T 0901317 |
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| Description | Potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR). Purity 98%. MW (observed): 481.33 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide |
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| Gene, Accession, CAS # | CAS: 293754-55-9 |
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| Catalog # | 2373/50 |
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| Price | |
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| Order / More Info | T 0901317 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 24812009, 25184494, 27695056, 27869139, 28369131, 28560318, 28926619, 29643332 |
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