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| Product Name | uPSEM 792 hydrochloride |
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| Description | Ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant. Purity 96%. MW (observed): 277.75 |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 6865/5 |
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| Order / More Info | uPSEM 792 hydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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