| 产品详情 |
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| Antigenic Specificity | TOK-1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TOK-1 Polyclonal Antibody. This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described fo |
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| Immunogen | n/a |
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| Other Names | TOK1; TOK-1 |
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| Gene, Accession # | Entrez: 361666, 56647, 66165; Uniprot: Q9CWI3, Q9P287 |
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| Catalog # | PA5-76424 |
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| Price | |
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| Order / More Info | TOK-1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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