| Edit |   |
|---|
| Antigenic Specificity | PPM1D |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µl |
|---|
| Concentration | n/a |
|---|
| Applications | Immunocytochemistry: 1-4 µg/mL, Immunofluorescence: 1-4 µg/mL, Immunohistochemistry: 1:200-1:500 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | PPM1D Polyclonal Antibody. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This ge |
|---|
| Immunogen | n/a |
|---|
| Other Names | Protein phosphatase 2C delta isoform; PP2C-delta; p53-induced protein phosphatase 1; Protein phosphatase magnesium-dependent 1 delta; WIP1 |
|---|
| Gene, Accession # | Entrez: 8493; Uniprot: O15297 |
|---|
| Catalog # | PA5-54583 |
|---|
| Price | |
|---|
| Order / More Info | PPM1D Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|