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| Product Name | Recombinant Mouse IL-17A/F Heterodimer (carrier-free) |
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| Description | IL-17A/F is part of the IL-17 cytokine family which consists of six structurally related proteins (IL-17A, B, C, D, E, and F). IL-17A is expressed primarily by Th17 cells, a subset of CD4 T cells. IL-17F is most closely related to IL-17A. The two molecules share 50% amino acid sequence homology. Like IL-17A, IL-17F mRNA and protein have been detected in Th17 cells. L-17F and IL-17A exist as a homodimers, adopting a cysteine knot motif formed through the interactions of four cysteines, one of which is responsible for the interchain bonding. IL-17F and IL-17A can form both homodimeric and heterodimeric proteins when expressed in a recombinant system and all forms of the recombinant proteins have in vitro functional activity. Mouse Th17 cells secret IL-17A/F as well as the homodimers IL-17A and IL-17F. IL-17A/F induces IL-6 and KC (CXCL1) production in mouse fibroblast and macrophages.IL-17A/F signals through IL-17A and TRAF6. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | IL-17A/IL-17F |
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| Gene, Accession, CAS # | Gene ID: 16171, 257630 |
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| Catalog # | 580804 |
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| Price | |
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| Order / More Info | Recombinant Mouse IL-17A/F Heterodimer (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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