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| Product Name | PF 5274857 hydrochloride |
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| Description | High affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant. Purity 98%. MW (observed): 473.42 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride |
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| Gene, Accession, CAS # | CAS: 1613439-62-5 |
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| Catalog # | 5262/10 |
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| Price | |
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| Order / More Info | PF 5274857 hydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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