| 产品详情 |
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| Product Name | JGB1741 |
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| Description | Purity ≥98%. MW: 440.56. JGB1741 is a small molecule inhibitor of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. The IC50 value of JGB1741 in a cell-free assay is 15 µM. The IC50 for cell proliferation of three cancer cell lines, K562, HepG2 and MDA-MB 231 is 1 µM, 10 µM and 0.5 µM, respectively. JGB1741 causes cytochrome c release, modulation in Bax/Bcl2 ratio and cleavage of PARP. |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-benzo[b]thiophene-3-carboxamide |
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| Gene, Accession, CAS # | CAS: 1256375-38-8 |
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| Catalog # | B2804-1 |
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| Order / More Info | JGB1741 from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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