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| Product Name | JH-II-127 |
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| Description | JH-II-127 is a highly potent, selective, and cell-permeable LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 µM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg. MW: 416.87. Purity ≥98% by HPLC |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone |
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| Gene, Accession, CAS # | CAS: 1700693-08-8 |
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| Catalog # | 9632-25 |
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| Price | |
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| Order / More Info | JH-II-127 from BIOVISION, INC. |
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| Product Specific References | n/a |
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