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| Product Name | SETD2 (KMT3A) Protein |
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| Description | 1425-1717. MW: ~61 kDa. Description: Recombinant human SETD2 (KMT3A) (1425-1717) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: As a member of the mixed lineage leukaemia (MLL) family of histone methyltransferase, SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. The main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. |
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| Size | 0.02 mg, 0.05 mg |
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| Concentration | n/a |
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| Applications | Enzyme Function Tests |
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| Other Names | [Homo sapiens SET domain containing 2 (SETD2), transcript variant 1, mRNA; Histone-lysine N-methyltransferase SETD2; histone-lysine N-methyltransferase SETD2; SET domain containing 2; HIF-1; Huntingtin yeast partner B; Huntingtin-interacting protein 1; HIP-1; Huntingtin-interacting protein B; Lysine N-methyltransferase 3A; SET domain-containing protein 2; hSET2; p231HBP] |
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| Gene, Accession, CAS # | SETD2, Gene ID: 29072, Accession: NM_014159.6 |
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| Catalog # | MBS515669 |
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| Order / More Info | SETD2 (KMT3A) Protein from MYBIOSOURCE INC. |
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| Product Specific References | 1. Li Y, et al: Structural basis for activity regulation of MLL family methyltransferases. Nature. 530 (7591):447-52. 2016 2. http://www.uniprot.org/uniprot/Q9BYW2 |
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