| 产品详情 |
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| Antigenic Specificity | BRCA1 |
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| Clone | MS110 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Immunohistochemistry (Frozen): 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:100, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BRCA1 Monoclonal Antibody (MS110). BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80 |
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| Immunogen | n/a |
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| Other Names | Breast Cancer 1 Early Onset, RNF53, RING Finger Protein 53, BROVCA12, Breast And Ovarian Cancer Susceptibility Protein 1, IRIS, PSCP, BRCC1 |
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| Gene, Accession # | Entrez: 672; Uniprot: P38398 |
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| Catalog # | MA1-137 |
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| Price | |
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| Order / More Info | BRCA1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 25400221, 28607489 |
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