| 产品详情 |
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| Product Name | Sertindole |
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| Description | An atypical antipsychotic; binds to D2 dopamine and 5-HT1D, 5-HT2A, and 5-HT2C receptors (Kds = 2.7, 20, 0.14, and 6 nM, respectively); binds to histamine H1 and α1- and α2-adrenergic receptors (Kds = 320, 3.9, and 190 nM, respectively); increases extracellular dopamine, ACh, and glutamate levels in the medial prefrontal cortex in concious rats at 10 mg/kg; reverses ketamine-induced impairments in the extradimensional shift stage of the ASST in rats at 2.5 mg/kg; reverses phencyclidine-induced selective reversal learning deficits in rats and subchronic phencyclidine-induced deficits in the novel object recognition task in mice; prevents accuracy deficits and anticipatory over-responding in the 5CSRTT in rats |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Lu 23-174 Lu23-174 Lu23174 serdolect serlect zerdol anti-psychotic D-2 5HT 5-HT-1D 2A 2C H-1 α-1 2 extra-dimensional 5-CSRTT Phencyclidine N-methyl-D-aspartate RCPP |
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| Gene, Accession, CAS # | CAS: 106516-24-9 |
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| Catalog # | 23883-10 |
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| Price | |
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| Order / More Info | Sertindole from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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