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| Product Name | Recombinant Human FGF-8a (carrier-free) |
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| Description | FGF-8 belongs to the fibroblast growth factor (FGF) family and plays an important role in cell growth, embryogenesis, and tumorigenesis. Four isoforms of FGF-8 in human (a, b, e, f) and eight isoforms in mouse (a-h) generated by alternative splicing of the mRNA have been described. Comparing human and mouse, FGF-8a and FGF-8b show identical sequence homology. FGF-8b is predominant form and co-expressed with FGF-8a. The isoforms have different biological functions during embryogenesis. During prenatal stages, FGF-8 is required for the normal development of various organs, including limbs and central nervous system. Misexpression of FGF-8a and 8b proteins results in dysregulation of fate determination in developing brain. In addition, FGF-8 was first cloned from SC-3 mouse mammary carcinoma cells and was found to be induced in response to androgenic stimuli. The isoform FGF-8b has the highest affinity to FGF receptors, elucidating the stronger transforming capacity than FGF-8a. FGF-8b is detected in human prostate and breast carcinoma specimens and cell lines. FGF-8f is associated with the prognosis of esophageal carcinomas. FGF-8e mutation is associated with deficiency of gonadotropin-releasing hormone (GnRH). |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Fibroblast growth factor 8, FGF8, Androgen-induced growth factor, AIGF, Heparin-binding growth factor 8, HBGF-8 |
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| Gene, Accession, CAS # | Gene ID: 2253 |
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| Catalog # | 773508 |
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| Order / More Info | Recombinant Human FGF-8a (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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