| 产品详情 |
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| Antigenic Specificity | CARM1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 ul |
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| Concentration | n/a |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit polyclonal to CARM1.Coactivator-associated arginine methyltransferase 1 (CARM1) is also known as Protein arginine Nmethyltransferase4 (PRMT4), which catalyze the transfer of a methyl group from S-adenosyl-Lmethionineto the side chain nitrogens of arginine residues within proteins to form methylated argininederivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated insignal transduction, metabolism of nascent pre-RNA, and transcriptional activation Methylates (monoandasymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involvedin DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. CARM1 isrecruited to promoters upon gene activation together with histone acetyltransferases fromEP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainlyasymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. |
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| Immunogen | C-terminal region of human CARM1 |
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| Other Names | CARM1,Histonearginine methyltransferase CARM1,Coactivatorassociated arginine methyltransferase 1,Protein arginine Nmethyltransferase 4,PRMT4 |
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| Gene, Accession # | UniProt: Q86X55 |
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| Catalog # | orb67015 |
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| Price | |
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| Order / More Info | CARM1 Antibody from BIORBYT LTD. |
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| Product Specific References | n/a |
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