| 产品详情 |
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| Product Name | IWP-4 |
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| Description | IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC50 = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 µM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells. MW: 496.62. Purity ≥95% by HPLC |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-?(6-?methyl-?2-?benzothiazolyl)-?2-?[[3,?4,?6,?7-?tetrahydro-?3-?(2-?methoxyphenyl)-?4-?oxothieno[3,?2-?d]pyrimidin-?2-?yl]thio]-?acetamide |
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| Gene, Accession, CAS # | CAS: 686772-17-8 |
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| Catalog # | 2650-1 |
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| Price | |
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| Order / More Info | IWP-4 from BIOVISION, INC. |
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| Product Specific References | n/a |
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