| 产品详情 |
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| Product Name | XMU-MP-1 |
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| Description | Purity ≥98%. MW: 416.47. XMU-MP-1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 µM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. Enhances activity of downstream YAP in vitro. |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | XMU-MP1; XMUMP 1; 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamid |
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| Gene, Accession, CAS # | CAS: 2061980-01-4 |
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| Catalog # | B2498-25 |
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| Price | |
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| Order / More Info | XMU-MP-1 from BIOVISION, INC. |
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| Product Specific References | n/a |
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