| 产品详情 |
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| Antigenic Specificity | CD8 Antigen, alpha Chain (CD8A) |
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| Clone | 53-6-7 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a |
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| Format | biotin conjugate |
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| Size | 0.5 mg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunohistochemistry (IHC),Immunoprecipitation (IP) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an chain (CD8/Lyt-2) and a chain (CD8/Lyt-3), and (ii) a homodimer of two chains. The heterodimer is found on the surface of essentially all thymocytes and the suppressor/cytotoxic subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8 without CD8. It has been suggested that CD8+- T cells mature extrathymically, while development of the CD8++ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8+ cells. |
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| Immunogen | n/a |
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| Other Names | BB154331|Ly-2|Ly-35|Ly-B|Lyt-2|zgc:136643|cd8|LOC100136450 |
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| Gene, Accession # | Gene ID: 12525 |
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| Catalog # | ABIN135121 |
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| Price | |
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| Order / More Info | CD8 Antigen, alpha Chain (CD8A) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 1786079, 6757107, 6156984, 1716278, 2697086 |
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