产品名称 Recombinant Human G-CSF (Animal-Free) from BIOLEGEND
产品货号 713402
产品价格 现货询价,电话:010-67529703
产品规格 10 µg
产品品牌 BIOLEGEND
产品概述
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Product NameRecombinant Human G-CSF (Animal-Free)
DescriptionHuman G-CSF was cloned from a human squamous carcinoma cell line and is the key hematopoietic cytokine involved in the control of neutrophil development. Therefore, it is a critical regulator of innate immunity against bacterial infections. G-CSF mobilizes stem cells indirectly by downregulating the expression of CXCL12 on marrow osteoblasts and by releasing neutrophil and monocyte proteolytic enzymes, including neutrophil elastase, cathepsin G, and matrix metalloproteinase-9. This in turn degrades important HSC trafficking and adhesion molecules, such as c-kit, VCAM-1, and CXCR4. In addition, G-CSF possesses immunosuppressive effects on monocytes/macrophages, dendritic cells, and T cells. The receptor for G-CSF is expressed not only in hematopoietic cells; it is also expressed in cardiomyocytes, skeletal muscle, and neurons. G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation. In vitro, G-CSF displays strong antiapoptotic activity in neuronal cells.     
Size10 µg
Concentrationn/a
ApplicationsBA
Other NamesGranulocyte-Colony Stimulating Factor, CSF3, CSF-β, Pluripoietin, Granulocytic neutrophil colony stimulating activity (G-CSA), Macrophage-granulocyte inducer-2 (MGI-2), GCSF
Gene, Accession, CAS #Gene ID: 1441
Catalog #713402
Price
Order / More InfoRecombinant Human G-CSF (Animal-Free) from BIOLEGEND
Product Specific Referencesn/a
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