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| Product Name | Recombinant Mouse CD112R-Fc Chimera (carrier-free) |
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| Description | CD112R gene encodes a single transmembrane protein consisting of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain which contains two tyrosine residues, one within an ITIM-like motif. CD112R was initially named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes. CD112R is a cell surface receptor for CD112/Nectin-2 and may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with CD112, CD112R inhibits T-cell proliferation and the disruption of interaction between CD112R and CD112 enhances T cell response, suggesting CD112R is a novel checkpoint for human T cells. CD112R competes with CD226 for CD112 binding. It has been shown the blockade of CD112R enhances Trastuzumab (first-line drug to treat breast cancer with high Her2 expression) triggered antitumor response by human NK cells. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Poliovirus receptor-related immunoglobulin domain containing protein, PVRIG, C7orf15, CD112 receptor |
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| Gene, Accession, CAS # | Gene ID: 620147 |
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| Catalog # | 776604 |
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| Order / More Info | Recombinant Mouse CD112R-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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