| 产品详情 |
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| Product Name | p-nitro-Pifithrin-Alpha |
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| Description | Purity >95%. Pifithrin-Alpha is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. p -nitro-Pifithrin-Alpha is a cell-permeable analog of pifithrin-Alpha. It blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-Alpha. p- nitro-Pifithrin-Alpha, at 10 µM, suppresses p53-mediated TGF-Beta1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet. It is slowly converted into a more potent cyclized form, p- nitro cyclic pifithrin-Alpha, when incubated in biological media (t1/2 = 8 h). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(4-nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-ethanone, monohydrobromide, p-nitro-PFT-Alpha |
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| Gene, Accession, CAS # | CAS: 389850-21-9 |
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| Catalog # | LS-H9466 |
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| Price | |
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| Order / More Info | p-nitro-Pifithrin-Alpha from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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